Clinical Trials with Nutrients & Natural Products/Substances

Camfield  DA, Scholey A, Pipingas A, Silberstein R,  Kras M, Nolidin K, Wesnes K, Pace M, Stough C (2012). Steady state visually evoked potential (SSVEP) topography changes associated with cocoa flavanol consumption. Physiology & Behavior 105: 948-957.


Ellis KA, Stough C, Vitetta L, Heinrich K, Nathan PJ (2001). An investigation into the acute nootropic effects of hypericum perforatum L. (St John's Wort) in healthy human volunteers. Behavioural Pharmacology. 12: 173-182.


Ford CE, Scholey AB, Ayre G, Wesnes KA (2002). The effect of glucose administration and the emotional content of words on heart rate and memory. Journal of Psychopharmacology. 16: 241-244. 


Harrison BJ, Oliver JS, Norman TR, Burrows GD, Wesnes KA, Nathan PJ (2004). Selective effects of acute serotonin and catecholamine depletion on memory in healthy women. Journal of Psychopharmacology. 18: 32-40.


Haskell CF, Kennedy D, Milne AL, Wesnes KA, Scholey AB (2008). The effects of L-theanine, caffeine and their combination on cognition and mood. Biological Psychology. 77: 113-122. 


Haskell CF, Kennedy DO, Wesnes KA, Milne AL, Scholey AB (2007). A double-blind, placebo-controlled, multi-dose evaluation of the acute behavioural effects of guarana in humans. Journal of Psychopharmacology. 21: 65-70. 


Haskell CF, Kennedy DO, Wesnes KA, Scholey AB (2005). Cognitive and mood improvements of caffeine in habitual consumers and habitual non-consumers of caffeine. Psychopharmacology. 179: 813-825. 


Ingwersen J, Defeyter MA, Kennedy DO, Wesnes KA, Scholey AB (2007). A low glycaemic index breakfast cereal preferentially prevents children's cognitive performance from declining throughout the morning. Appetite. 49: 240 -244. 


Isaacs E, Oates J (2008). Nutrition and cognition: assessing cognitive abilities in children and young people. European Journal of Nutrition. 47(3): 4-24


Jones EK, Sünram-Lea SI, Wesnes KA. (2012). Acute ingestion of different macronutrients differentially enhances aspects of memory and attention in

healthy young adults. Biological Psychology 89: 477-468.


Kennedy D, Haskell CF, Mauri P, Scholey AB (2007). Acute cognitive effects of standardised Ginkgo Biloba extract complexed with phosphatidylserine. Human Psychopharmacology. 22: 199–210. 


Kennedy D, Jackson P, Haskell CF, Scholey AB (2007). Modulation of cognitive performance following single doses of 120 mg Ginkgo biloba extract administered to healthy young volunteers. Human Psychopharmacology. 22: 559-566. 


Kennedy DO, Haskell CF, Wesnes KA, Scholey AB (2004). Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract: comparison and interaction with Panax ginseng. Pharmacology, Biochemistry and Behaviour. 79: 401-411. 


Kennedy DO, Jackson PA, Elliott JM, Scholey AB, Robertson BC, Greer J, Tiplady B, Buchanan T, Haskell CF (2009). Cognitive and mood effects of 8 weeks' supplementation with 400 mg or 1000 mg of the omega-3 essential fatty acid docosahexaenoic acid (DHA) in healthy children aged 10-12 years. Nutritional Neuroscience. 12: 48-56.


Kennedy DO, Raey JL, Scholey AB (2007). Effects of 8 weeks administration of Korean Panax ginseng extract on the mood and cognitive performance of healthy individuals. Journal of Ginseng Research. 31: 34-43. 


Kennedy DO, Scholey AB, Tildesley NT, Perry EK, Wesnes KA (2002). Modulation of mood and cognitive performance following acute administration of Melissa officinalis (lemon balm). Pharmacology, Biochemistry and Behaviour. 72: 953-964. 


Kennedy DO, Scholey AB, Wesnes KA (2000). The dose-dependent cognitive effects of acute administration of Ginkgo biloba to healthy young volunteers. Psychopharmacology. 151: 416-423. 


Kennedy DO, Scholey AB, Wesnes KA (2001). Differential, dose dependent changes in cognitive performance following acute administration of a Ginkgo biloba/Panax ginseng combination to healthy young volunteers. Nutritional Neuroscience. 4: 399-412. 


Kennedy DO, Scholey AB, Wesnes KA (2001). Dose dependent changes in cognitive performance and mood following acute administration of Ginseng to healthy young volunteers. Nutritional Neuroscience. 4: 295-310. 


Kennedy DO, Scholey AB, Wesnes KA (2002). Modulation of cognition and mood following administration of single doses of Ginkgo biloba, ginseng, and a ginkgo/ginseng combination to healthy young adults. Physiology & Behaviour. 75: 739-751. 


Kennedy DO, Wake G, Savelev S, Tildesley NT, Perry EK, Wesnes KA, Scholey AB (2003). Modulation of mood and cognitive performance following acute administration of single doses of melissa officinalis (lemon balm) with human CNS nicotinic and muscarinic receptor-binding properties. Neuropsychopharmacology. 28: 1871-1881. 


Mace J, Porter R, Dalrymple-Alford J, Wesnes KA, Anderson T (2011). The effects of acute tryptophan depletion on neuropsychological function, mood and movement in the healthy elderly. Journal of Psychopharmacology 25: 1337-1343.


Maher BF, Stough C, Shelmerdine A, Wesnes KA, Nathan PJ (2002). The acute effects of combined administration of Ginkgo biloba and Bacopa monniera on cognitive function in humans. Human Psychopharmacology. 17: 163-164.


Matrenza C, Hughes JM, Kemp AH, Wesnes KA, Harrison BJ, Nathan PJ (2004). Simultaneous depletion of serotonin and catecholamines impairs sustained attention in healthy female subjects without affecting learning and memory. Journal of Psychopharmacology. 18: 21-31.


Moss L, Rouse M, Wesnes KA, Moss M (2010). Differential Effects of the Aromas of Salvia Species on Memory and Mood. Human Psychopharmacology: Clinical and Experimental 25: 388-396.


Moss M, Cook J, Wesnes KA, Duckett P (2003). Aromas of rosemary and lavender essential oils differentially affect cognition and mood in healthy adults. International Journal of Neuroscience. 113: 15-38. 


Moss M, Hewitt S, Moss L, Wesnes KA (2008). Modulation of cognitive performance and mood by aromas of peppermint and ylang-ylang The International Journal of Neuroscience. 118: 59-77. 


Moss M, Howarth R, Wilkinson L, Wesnes KA (2006). Expectancy and the aroma of roman chamomile influence mood and cognition in healthy volunteers. International Journal of Aromatherapy. 16: 63-73.


Moss MC, Scholey AB, Wesnes KA (1998). Oxygen administration selectively enhances cognitive performance in healthy young adults: a placebo-controlled double-blind crossover study. Psychopharmacology. 138: 27-33. 


Nathan PJ, Ricketts E, Wesnes KA, Mrazek L, Greville W, Stough C (2002). The acute nootropic effects of Ginkgo biloba in healthy older human subjects: a preliminary investigation. Human Psychopharmacology. 17: 45-49.


Pase M, Scholey A, Pipingas Andrew, Kras M, Nolidin K, Gibbs A, Wesnes K, Stough C. (2013). Cocoa polyphenols enhance positive mood states but not cognitive performance: a randomized, placebo-controlled trial. Journal of Psychopharmacology 27: 451-458.


Pengelly A, Snow J, Mills SY, Scholey A, Wesnes K, Butler LR. (2012). Short-Term Study on the Effects of Rosemary on Cognitive Function in an Elderly Population. Journal of Medicinal Food 15: 10-17.


Ryan J, Croft K, Mori T, Wesnes KA, Spong J, Downey LA, Kure C, Lloyd J, Stough C (2008). An examination of the effects of the antioxidant Pycnogenol on cognitive performance, serum lipid profile, endocrinological and oxidative stress biomarkers in an elderly population. Journal of Psychopharmacology. 22: 553-562. 


Scholey A, Tildesley NT, Ballard CG, Wesnes KA, Tasker A, Perry EK, Kennedy DO (2008). An extract of Salvia (sage) with anticholinesterase properties improves memory and attention in healthy older volunteers. Psychopharmacology 198: 127-139. 


Scholey AB, Kennedy D, Wesnes KA (2005). The psychopharmacology of herbal extracts: issues and challenges. Psychopharmacology. 179: 705-707.


Scholey AB, Kennedy DO (2004). Cognitive and physiological effects of an "energy drink": an evaluation of the whole drink and of glucose, caffeine and herbal flavouring fractions. Psychopharmacology. 176: 320-330. 


Scholey AB, Moss MC, Neave N, Wesnes KA (1999). Cognitive performance, hyperoxia, and heart rate following oxygen administration in healthy young adults. Physiology and Behaviour. 67: 783-789. 


Scholey AB, Moss MC, Wesnes KA (1998). Oxygen and cognitive performance: the temporal relationship between hyperoxia and enhanced memory. Psychopharmacology. 140: 123-126. 


Stough C, Downey L, Sibler B, Lloyd J, Kure C, Wesnes K, Camfield D. (2012). The effects of 90-day supplementation with the Omega-3 essential fatty acid docosahexaenoic acid (DHA) on cognitive function and visual acuity in a healthy aging population. Neurobiology of Aging 33:824.e1-3.


Stough C, Downey LA, Lloyd J, Silber B, Redman S, Hutchison C, Wesnes KA, Pradeep NJ (2008). Examining the nootropic effects of a special extract of bacopa monniera on human cognitive functioning: 90 day double blind placebo-controlled randomized trial. Phytotherapy Research. 22: 1629-1634. 


Stough C, Kure C, Tarasuik J, Lloyd J, Downey L, Scholey A, Wesnes A (2009). A Randomized, Double-blind, Placebo Controlled Study Examining the Effects of a Combination Nutraceutical Formula on Cognitive Functioning and Mood. Journal of the American Nutraceutical Association  12: 12-19.


Stough C, Pase MP, Cropley V, Myers K, Nolidin R, Camfield D,  Wesnes K, Pipingas A, Croft K, Chang D,  Scholey AB (2012). A randomized controlled trial investigating the effect of Pycnogenol and CDRI08 herbal medicines on cognitive, cardiovascular, and biochemical functioning in cognitively healthy elderly people: the Australian Research Council Longevity Intervention (ARCLI) study protocol (ACTRN12611000487910). Nutrition Journal 11:11 doi:10.1186/1475-2891-11-11


Stough C, Scholey A, Cropley V, Wesnes K, Zangara A, Pase M, Savage K, Downey LA (2013). Examining the cognitive effects of a special extract of Bacopa monniera (CDRI08: Keenmnd): A review of ten years of research at Swinburne University. Journal of Pharmacy & Pharmaceutical Sciences 11:11 doi:10.1186/1475-2891-11-11


Sűnram-Lea SI, Birchall RJ, Wesnes KA, Petrini O (2004). The effect of acute administration of 400MG of Panax Ginseng on cognitive performance and mood in healthy young volunteers. Current topics in Nutraceutical Research. 3: 251-254. 


Taib MNM, Shariff ZM, Saad SL, Wesnes KA, Sariman S. (2011). The effect of lactose-isomaltulose on cognitive performance of young children: a double blind cross-over design study. Appetite 58: 81-87.


Tildesley NT, Kennedy DO, Perry EK, Ballard CG, Savelev S, Wesnes KA, Scholey AB (2003). Salvia lavandulaefolia (Spanish sage) enhances memory in healthy young volunteers. Pharmacology, Biochemistry and Behaviour. 75: 669-674. 


Tildesley NT, Kennedy DO, Perry EK, Ballard CG, Wesnes KA, Scholey AB (2005). Positive modulation of mood and cognitive performance following administration of acute doses of Salvia lavandulaefolia essential oil to healthy young volunteers. Physiology & Behaviour. 83: 699-709. 


Wesnes KA (2010). Cognition Enhancement – Expanding Opportunities in Drug Development. International Clinical Trials June 2010: 66-72.


Wesnes KA (2013) Natural substances as treatments for age-related cognitive declines. In: Advances in Natural Medicines, Nutraceuticals and Neurocognition. In C. Stough & A. Scholey (Eds), CRC Press, Taylor & Francis, Boca Raton. ISBN 9781439893609.


Wesnes KA, Zangara A (2004). Natural products as cognition enhancing agents. Cognition Enhancing Drugs. J. J. Buccafusco. Basel, Birkhauser Verlag: 151– 178.


Wesnes KA, Barrett M, Udani J. (2013) An evaluation of the cognitive and mood effects of an energy shot over a 6 hour period in volunteers: A randomized, double-blind, placebo controlled, cross-over study. Appetite  DOI: 10.1016/j.appet.2013.04.005


Wesnes KA, Faleni RA, Hefting NR, Hoogsteen G, Houben JJ, Jenkins E, Jonkman JH, Leonard J, Petrini O, van Lier JJ (1997). The cognitive, subjective, and physical effects of a ginkgo biloba/panax ginseng combination in healthy volunteers with neurasthenic complaints. Psychopharmacology Bulletin. 33: 677-683. 


Wesnes KA, Pincock C, Richardson D, Helm G, Hails S (2003). Breakfast reduces declines in attention and memory over the morning in school children. Appetite. 41: 329-331. 


Wesnes KA, Warburton DM (1983). Effects of scopolamine on stimulus sensitivity and response bias in a visual vigilance task. Neuropsychobiology. 9: 154-157.


Wesnes KA, Ward T, McGinty A, Petrini O (2000). The memory enhancing effects of a ginkgo biloba/panax ginseng combination in healthy middle-aged volunteers. Psychopharmacology. 152: 353-361. 


Wilkinson L, Scholey AB ,Wesnes KA (2002). Chewing gum selectively improves aspects of memory in healthy volunteers Appetite 38: 235-236.


Zangara A, Wesnes KA (2013) Herbal cognitive enhancers: New developments and challenges for therapeutic applications. In: M.K.Thakur & I.S. Suresh (Eds). Brain Aging and Therapeutic Interventions, Springer. ISBN 978-94-007-5237-5. pp 267-289.

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